Six months of supplementation with the Dose for your Liver product by California-based Eetho Brands Inc. led to significant improvements in levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alanine phosphatase (ALP), and gamma-glutamyl transferase (GGT), compared to placebo. Eetho Brands funded the study.
“While previous reports have indicated the potential benefits of turmeric, dandelion, milk thistle and ginger on the liver individually, to the authors’ knowledge, this is the first report of the effects of these extracts combined in any form,” wrote scientists from Green Medic Solution (India), Unity Hospital (Gujarat, India), OvationLab (USA) and the University of Maryland School of Medicine (USA) in Frontiers in Nutrition.
“Moreover, this is the first report of these extracts combined in a liquid, single-use format and with a dried colloidal suspension of turmeric with enhanced bioavailability compared with standard turmeric extracts.”
Liver health
Supplements to support liver health represent a small but growing category within the wider supplements space. The category is dominated by milk thistle (Silybum marianum), which recorded about $39.7million in sales in the U.S. market (natural plus mainstream channels), according to the most recent Herb Market Report from the American Botanical Council (HerbalGram #144).
Liver health is usually measured using liver enzymes levels such as ALT and AST, the researchers on the new study explained.
“The overall prevalence of elevated liver enzymes has been increasing and is estimated to be approximately 10% of the U.S. population overall, with a markedly higher prevalence among certain subgroups. The prevalence of elevated liver enzymes among overweight and obese individuals, in particular, may be as high as 50%.”
Study details
The randomized, double-blind, placebo-controlled clinical trial focused on healthy people (average age 36.65) with normal liver function. Participants were randomly assigned to receive the Dose for your Liver product or placebo twice a day for 180 days. Each 60 mL oral dose provided 435 mg of a blend of turmeric extract (dried colloidal suspension), dandelion root powder, milk thistle seed extract and ginger powder.
Results showed that participants in the herbal blend group experienced significantly greater improvements in ALT, AST, ALP and GGT, while levels in the placebo group increased from baseline, “suggesting a trend of increasing subclinical liver stress in healthy individuals over time in the absence of proactive liver support,” the researchers reported.
“Progression to liver disease typically starts with steatosis (i.e., fatty liver), then progresses to elevated liver enzyme levels, fibrosis and, finally, cirrhosis,” they added. “Thus, reducing liver enzyme levels very early in the process suggests a proactive approach to slowing the progression of liver dysfunction.”
Participants taking the herbal combination also experienced improvements in their lipid profiles (total cholesterol and LDL cholesterol levels) and levels of inflammatory markers (CRP, IgA and IgE).
Importantly, no negative effects were recorded on hematological (CBC) or kidney function indicators, the researchers noted. No adverse events were reported in either group.
“The test product demonstrated an exceptional safety profile with repeated dosing, indicating that regular consumption is safe,” the researchers wrote. “These findings suggest the potential for lowering liver enzyme levels with repeated supplementation of this highly purified plant-based nutraceutical in healthy individuals who may have subclinical metabolic dysfunction or who are experiencing a trend of increasing liver enzyme levels over time.”
Source: Frontiers in Nutrition, Volume 12. doi: 10.3389/fnut.2025.1721748. “Long-term safety and efficacy of a highly purified plant-based nutraceutical for improving clinical parameters of liver function in healthy participants: a randomized, double-blind, placebo-controlled clinical trial”. Authors: G. Patel, et al.
