Science shorts: Spotlight on probiotic-phytonutrient blend, dAKG, iron and more

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Science shorts (Getty Images/Connect Images)

This round-up highlights the latest health and nutrition research findings, including how a probiotic-phytonutrient blend could improve gut function, the effects of delayed-release alpha-ketoglutarate (dAKG) on biological age reversal, iron supplementation for lowering the risk of pelvic inflammatory disease (PID) and more.

Probiotic–phytonutrient blends may improve gut function

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Probiotics, magnesium oxide and psyllium supplements and are among the endorsed dietary interventions for chronic constipation. (Keeproll/Getty Images/Keep Roll)

Probiotic–phytonutrient blends containing Lacticaseibacillus and Bifidobacterium strains plus citrus bioflavonoids and dandelion root extract could improve bowel function and gut health, according to a new study.

Writing in Nutrients, researchers from South Korea and the US suggested that supplementation may influence gut microbial activity and gut barrier-related biomarkers through microbiome-mediated metabolic modulation.

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The eight-week study also reported that probiotic–phytonutrient blends increased short-chain fatty acid levels, especially butyrate and acetate.

Sustained-release melatonin may boost sleep outcomes and wellbeing for poor sleepers: RCT

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Study results indicated improvements in sleep-related impairment in the saffron group (Guido Mieth/Getty Images)

A low dose of sustained-release melatonin may improve sleep quality, including falling asleep faster and fewer nighttime awakenings.

This is based on a 28-day study which evaluated the melatonin ingredient branded Melotime from India-based Nutriventia.

Findings published in Clocks & Sleep reported that the intervention group fell asleep approximately 10 minutes faster on average post-trial, while that of the placebo group was lengthened by over 15 minutes.

dAKG associated with biological age reversal

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Ageing could be measure by looking at the chronological age and biological age. © Getty Images (mikkelwilliam/Getty Images)

Supplementation of delayed-release alpha-ketoglutarate (dAKG) could reverse biological age, says a new study from Singapore.

The study, led by researchers from the Healthy Longevity Translational Research Programme, part of the National University of Singapore, assessed the association between 84 commonly used supplements and biological age measured as Age Residual.

Findings published in Aging Cell showed that supplement users had significantly younger Age Residual than non-users, based on cross-sectional analysis. A non-significant benefit of taking supplements was also seen in the longitudinal analysis.

Lutein-zeaxanthin supplements may boost attention in teenagers: RCT

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A new clinical trial tested the effects of lutein and zeaxanthin supplements in teenagers with a high use of screens and a diet low in fruits and vegetables (Alistair Berg/Getty Images)

Daily supplementation with lutein and zeaxanthin may boost attention and processing speed in teenagers, says a new clinical trial that claims to be the first to study the effects of the carotenoids in teenagers.

Writing in Nutrition Research, researchers from Australia reported that supplementation with 10 mg lutein and 2 mg of zeaxanthin per day was also associated with increases in macula pigment optical density (MPOD) – a measure of lutein/zeaxanthin levels in the eye.

The study used the Lute-gen ingredient from Bio-gen Extracts Pvt. Ltd, which also funded the trial.

Can iron intake combat pelvic inflammatory disease?

It is estimated that annually 500,000 to 1,000,000 women in the United States have PID
It is estimated that annually 500,000 to 1,000,000 women in the United States have PID. (@ Keeproll / Getty Images)

Women who consumed iron had a significantly lower risk of developing pelvic inflammatory disease (PID), especially when the mineral was taken at a specific dose range.

Writing in the journal Medicine, researchers at Nanjing Medical University in China used data from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2020 to explore the possible link between dietary iron consumption and PID.

Notably, participants with the highest iron use experienced a 30% reduction in PID risk.