Launched in 2022, Dermial’s hero ingredient is a high-concentration hyaluronic acid matrix, a naturally occurring substance in the human body that is primarily found in the skin, eyes and connective tissues. It is a type of glycosaminoglycan (GAG) and is best known for its ability to retain moisture as it is able to hold up to 1,000 times its weight in water. The hyaluronic acid matrix (HAm) formula also contains dermatan sulfate and collagen to keep skin nourished and hydrated.
According to Antonio Vendrell, marketing and communications director at Bioiberica, consumers are waking up to hyaluronic acid supplements as a growing body of evidence links skin aging to diet.
“As more and more consumers recognize that healthy and glowing skin is the result of a healthy diet, many are now looking for beauty supplements to support this,” he told NutraIngredients.
Market research firm Precedence Research estimated the global hyaluronic acid market size to be US$ 11.14 billion in 2024, with US$ 2,363.7 million of that attributed to hyaluronic supplement sales (Future Market Insights).
Ageless beauty
Conducted by Bioiberica and published in Dermatology and Therapy, Vendrell said the new research “confirms the clinical effect of Dermial, the first hyaluronic acid matrix ingredient for skin and beauty.”
While the results showed that intervention improved skin appearance markers across ages in the group of 60 healthy women between the ages of 35 and 60, participants over the age of 55 showed significant improvements at earlier time points compared to younger participants.
This included improvements across many skin barrier function parameters, including brightness/glow, hydration, deformability, smoothness, roughness, scaliness and temperature.
“These new findings suggest Dermial can address age-related skin concerns, such as the appearance of wrinkles and fine lines, dryness, dullness, roughness and loss of firmness, by improving the skin’s barrier function and microtopography,” Vendrell said.
According to Euromonitor’s latest Voice of the Consumer: Health and Nutrition Survey, 27% of global respondents ages 45 to 59 reported using vitamins and dietary supplements specifically for beauty and skin health, up from 25% in 2024.
“This growing adoption among older demographics highlights the expanding appeal of beauty supplements beyond younger consumers and underscores the shift towards more holistic approaches to health and wellness across age groups,” Aishwarya Rajpara, health and beauty consultant at Euromonitor International, told NI.
Oral hyaluronic acid improves skin hydration
The randomized, double-blind, placebo-controlled clinical trial was conducted at the Dermatology Department of Hospital Universitario Virgen de las Nieves de Granada.
It assigned women with natural signs of facial aging to consume either a daily dose of 60 mg of Dermial or a placebo for 12 weeks. A dermatologist evaluated participants at baseline, week six and week 12.
Researchers evaluated skin parameters such as hydration, temperature, pH, elasticity, erythema and melanin. They assessed brightness, deformability, friction and skin hardness and measured antioxidant capacity via electrochemical methods. They also assessed skin surface parameters including smoothness, roughness, scaliness and wrinkles.
Findings indicated that daily participants in the supplementation group experienced enhanced skin hydration, brightness, smoothness and reduced roughness, wrinkles, scaliness and erythema.
Supplementation with Dermial was also found to boost skin hydration, particularly in the periocular area and cheek, supporting existing research on hyaluronic acid’s water-retention capacity. It also increased skin brightness, which the study attributes to better hydration, reduced redness and smoother skin texture.
In addition, the researchers noted that an observed decrease in skin temperature is likely due to improved hydration and barrier function since well-hydrated skin tends to retain more water and lose less through evaporation—resulting in a lower surface temperature.
They highlighted the findings as novel for orally administered hyaluronic acid, as previous evidence focused mainly on injected treatments.
“HAm’s unique ability to increase skin brightness/glow is significant, as skin brightness is a key indicator of healthy and youthful skin,” they wrote.
“No previous clinical trials have evaluated the impact of oral HA on this skin property, but previously it has been observed that mesotherapy with HA can improve skin brightness.”
Journal: Dermatology and Therapy. “Supplementation with a New Hyaluronic Acid Matrix Ingredient Improves Skin Brightness, Hydration, Smoothness, and Roughness: Results from a Randomized, Double-Blinded, Placebo-Controlled Study”. doi: 10.1007/s13555-025-01447-6. Authors: Montero-Vilchez, T. et al..