Humann, the nitric oxide–focused supplement brand inspired by Nobel Prize–winning research, aims to redefine cardiovascular support. Its latest innovations reportedly connect nitric oxide science to measurable real-world outcomes.
“The most important evolution has been moving from ingredient innovation to full-scale category leadership in nitric oxide and cardiovascular performance,” Kocher told NI. “Our clinical research has gone beyond biomarker shifts to demonstrate measurable outcomes: improved circulation, faster recovery, sustained energy and overall vitality.”
Competitive edge in nitric oxide formulation
As claims about nitric oxide continue to rise in the sports and wellness sectors, Kocher said Humann’s competitive edge lies in its origin and ongoing commitment to the full nitric oxide pathway.
“What sets Humann apart is our foundation in Nobel Prize–winning science and our focus on the entire nitric oxide pathway, not just ingredients,” he said.
The company originated from a University of Texas Health Science Center research program led by Dr. Ferid Murad, one of the 1998 Nobel Prize recipients in Medicine. Since then, Kocher said, Humann has developed “proprietary processes, patented formulations and clinical research that ensure consistent nitric oxide activation regardless of individual biology.”
Third-party certifications, such as NSF Certified for Sport, support the company’s positioning with both elite athletes and general wellness consumers.
“This isn’t trend-driven innovation, it’s science-born innovation that delivers measurable cardiovascular and performance benefits,” Kocher added.
Supply chain built for institutional scale
Humann now supplies more than 160 athletic teams and institutional partners. Kocher said meeting this level of demand has required strategic investment across operations.
“Scaling successfully has required us to embed reliability into every layer of our operations,” he said. “We’ve built long-term partnerships for raw materials, implemented uncompromising quality systems and expanded our manufacturing capacity to ensure consistency at scale.”
Each batch is designed to perform like the one before it.
“This isn’t just supply chain management,” Kocher said. “It’s the infrastructure of trust, ensuring our science translates into dependable real-world performance for athletes, practitioners and consumers alike.”
Stronger compliance amid regulatory scrutiny
With FDA and FTC attention increasing around structure-function claims, Humann has expanded its compliance strategy to stay ahead of shifting requirements.
“We welcome rigorous oversight because it strengthens the industry and builds trust,” Kocher said. “Since 2023, we’ve expanded our safety and compliance programs, invested in more rigorous clinical substantiation and proactively aligned with evolving FDA and FTC guidance.”
The company’s operating principle, he added, is “science first, transparency always.”
Reframing nitric oxide for energy, recovery and aging
As consumer expectations shift from longevity to performance and resilience, Humann has responded by reframing nitric oxide beyond its traditional cardiovascular positioning.
“Consumers today want more than longevity; they want vitality, resilience and the ability to perform at their best at every stage of life,” Kocher said. “Our response has been to reframe nitric oxide as more than a cardiovascular molecule, it really is the foundation of human performance.”
This broader message, he added, positions the brand to support athletes and health-conscious consumers alike with multifunctional benefits related to energy, endurance, recovery and healthy aging.
Next steps: delivery systems, ingredient synergies and research partnerships
Humann’s pipeline includes expanded product formats, new ingredient combinations and strategic collaborations to bring nitric oxide science into more use cases.
“Our vision is to broaden access and build an ecosystem around cardiovascular health,” Kocher said. “That includes advancing delivery systems beyond supplements like functional foods, ready-to-drink options and institutional formats for athletic programs.”
Humann is also pursuing ingredient synergies that extend nitric oxide’s impact into areas like cognition and cellular health. On the research side, it is deepening its collaboration with academic institutions including The University of Texas.
“These collaborations both validate and accelerate our innovation, allowing us to deliver science-backed breakthroughs worldwide while advancing research into foundational vascular health and its far-reaching benefits,” Kocher said.
