Published in Journal of Dermatology & Cosmetology, the randomized, double-blind, placebo-controlled study enrolled 71 women between the ages of 33 and 66 showing visible signs of skin aging.
Conducted at the Centro Médico Complutense in Spain, the study assigned participants to consumer either a 225 mg capsule of the botanical Eternalyoung blend or a placebo, taken daily over a period of 12 weeks.
The results indicated that the supplement had a positive impact on several key parameters of skin aging—most notable was a 23% reduction in forehead wrinkle volume at 12 weeks.
“This study indicates that daily supplementation with Eternalyoung is associated with notable and clinically observed improvements in the key aspects of skin aging,” said Nuria Caturla, PhD, chief R&D officer for Monteloeder, a subsidiary of Suannutra. “We witnessed its ability to help improve the appearance of smoother skin, more even tone, enhanced radiance and moisturization, especially in subgroups with a compromised skin barrier. These findings further support the antiaging efficacy of the formulation building on existing evidence.”
The study serves as a follow-up to results obtained in a clinical trial conducted in 2023 in which subjects using the supplement experienced various skin condition improvements, including hydration, mitigation of trans-epidermal water loss, improved elasticity, reduction in crow’s feet wrinkles and improvement in skin thickness.
The present study deepened understanding through the incorporation of three-dimensional (3D) wrinkle analysis, optical assessments of gloss and pigmentation, and the analysis of additional facial regions. It also enrolled a diverse population of Latin, Caucasian and Asian participants, covering Fitzpatrick skin phototypes II to V.
3D discovery
The study’s endpoints included instrumental assessments of forehead gloss, forehead hydration, forehead wrinkle topography, transepidermal water loss and skin color indices.
Clinic visits occurred at baseline and after approximately two, four, eight and 12 weeks of intake. Endpoints were measured at all points unless specified.
Wrinkle-reduction efficacy was assessed using a three-dimensional scanning sensor that measures the fine skin surface details.
Results showed that improvements became visible by week four and continued to intensify through week 12. More than 80% of the volunteers in the treatment group experienced these positive changes, while the placebo group showed little to no change.
The supplemented group demonstrated a 20% improvement in forehead radiance, with effects particularly pronounced among participants with greater visible skin impairment at baseline.
Skin pigmentation also showed a notable reduction in the supplemented group as expressed by a 14% drop in melanin index.
Results further indicated a visible improvement in skin tone and brightness around the forehead, upper cheeks and around the eyes for supplement users, as well as better skin moisture retention, particularly among those with higher initial levels of trans-epidermal water loss.
The researchers noted study limitations including the exploratory sample size, the exclusive inclusion of female participants and the relatively short duration of the intervention. They suggested future investigations incorporate molecular biomarkers and extended follow-up periods.
Botanical beauty
Eternalyoung is a standardized blend of four botanical extracts: pomegranate (Punica granatum), sweet orange (Citrus sinensis), desert ginseng (f. Cistanche) and gotu kola (Centella asiatica). It is characterized by a minimum content of 2.5% verbascoside, 12.5% hesperidin, 3% punicalagins and 7% asiaticosides.
A previous in-vitro study on human dermal fibroblasts revealed the mechanisms through which Eternalyoung may help counteract skin aging.
Laboratory analysis showed that it may help reduce AGE (advanced glycation end products) accumulation and support fibroblast activity. This helps strengthen the skin, increases its firmness, helps protect skin cells from oxidative stress, supports a balanced melanin process and contributes to telomere integrity.
Widely recognized as a crucial biomarker of aging, telomeres are DNA sequences that shield chromosomes as cells divide. Telomeres typically shorten with time, signaling cell decline and aging. This negatively impacts the skin’s natural self-regenerative potential, leading to a reduction in collagen and elastin fibers.
Under the microscope, Eternalyoung was shown to reduce telomere shortening by activating telomerase activity.
“Eternalyoung supports skin vitality by acting on cellular mechanisms associated with visible aging,” Caturla said. “This composition brings together four botanicals that work in unison to provide multipath way holistic skin benefits. It exerts a positive impact on such factors as oxidative stress, skin hydration, elasticity, collagen preservation and telomere protection. These effects may contribute to a smoother, brighter and more even-toned appearance. It also restores skin barrier balance and moisture in dry or stressed skin.”
Source: Journal of Dermatology & Cosmetology. doi: 10.15406/jdc.2025.09.00305. “Efficacy of a botanical-based Nutricosmetic ingredient on skin aging-related markers in adult women”. Authors: Navarro P, García A, Jones J, et al.
