Ovomet and Ovoderm, which are compositionally identical but have different trade names to differentiate benefit areas, have more than 43 structure-function claims associated with them. The peptide version of each is water soluble, while the standard version contains undenatured collagen, elastin and hyaluronic acid.
Although initially launched last year, ongoing research is continuing to build the evidence for the ingredient, with 16 studies on Ovomet and Ovoderm providing new insights into the efficacy of the ingredients distributed in North America by CK Nutraceuticals.
“What makes Ovomet and Ovoderm particularly novel is that they support healthy aging through the extracellular matrix (ECM), delivering quantified collagen, elastin, hyaluronic acid and bioactive peptides together in a single sustainable ingredient,” said Collen Madden, vice president of innovation at CK Nutraceuticals. “This holistic approach aligns perfectly with the growing convergence of beauty, nutrition and longevity in the premium wellness market.”
According to Korean researchers, eggshell membrane (ESM) is a unique, protein-rich, double-layered fibrous meshwork located between the eggshell and the egg white. Although it is composed of nearly 500 different types of proteins, the major component of ESM is collagen. Other key constituents include fibronectin, osteopontin, chondroitin sulfate and hyaluronic acid.
“Despite its unique properties and composition of many beneficial substances, ESM has been underutilized in the food industry compared to other egg components, such as egg white and yolk,” the researchers wrote. “Recent studies, however, have reported beneficial effects of ESM, including antioxidant and anti-inflammatory activities, the promotion of gut health, and skin wound healing. Beyond its antioxidant and other health benefits, ESM shows particular promise in improving joint health.”
Studies in animal models have shown ESM to relieve pain related to osteoarthritis. ESM treatment can also reduce the loss of crucial components of healthy cartilage as well as preserve the structural integrity of cartilage in osteoarthritic joints. In a randomized, double-blind, placebo-controlled clinical trial in people published this year showed that ESM supplementation improved joint symptoms, functional capacity and quality of life in individuals with osteoarthritis.
A range of skin improvements
Ingredients like elastin and glucosamine in eggshell membrane promote cellular activity, enhance collagen production and reduce UV-induced damage. ESM may do even more than that for the skin.
A double-bind, randomized, placebo-controlled study included 100 women between 25 and 60 years old who received 600 mg per day of ESM (Ovoderm) or placebo for 12 weeks. As early as six weeks, ESM improved elasticity, dermal density and sagging. By the end of 12 weeks, ESM led to diminished wrinkling and significant improvements in hydration, as well as reductions in transepidermal water loss, desquamation and roughness for those participants in the experimental group.
“These results not only confirm the safety and efficacy of ESM as a nutraceutical but also underscore its potential as a sustainable bioactive ingredient for skincare formulations,” the researchers noted. “The absence of adverse effects highlights ESM’s suitability for long-term use, making it an attractive option for consumers seeking natural solutions to combat aging.”
The study, which appeared in the Journal of Functional Foods, was funded by Korea’s ministry of education and supported by the country’s National Research Foundation.
