''Appetite reducer'' to lower food intake and reduce body fat mass, DNF-10 is a new ingredient from S. cerevisiae, selecting peptides <10kDa. Acting on the gut-brain axis, DNF-10 regulates the mediators of satiety: benefits demonstrated after 1 week, with 4 clinical studies available in this white paper. A daily intake of 0.5 g significantly decreased caloric intake after the first week, resulting in significant body weight loss after 1 month. Measured with computed tomography, the weight loss is from a reduction in fat mass. Water soluble, DNF-10 can be used in a diversity of delivery systems.